Estimation of Famotidine from Tablet Formulations

1.0 OBJECTIVE                    

To provide the procedure for Estimation of Famotidine from Tablet Formulations

2.0 SCOPE

This procedure is Applicable to the Estimation of Famotidine from Tablet Formulations

3.0 RESPONSIBILITY

3.1 QC-Chemist 

4.0 ACCOUNTABILITY

4.1 Executive – Quality control

4.2 Head – Quality control

5.0 PROCEDURE  

 5.1Label Claim: 

Famotidine Tablets IP/USP ...... 40mg

5.2 Assay Method: 

5.2.1 Standard solution:  

Accurately weigh about 20mg of Famotidine working standard and transfer it into 100ml of volumetric flask, add 50 ml of double distilled water, shake well until the material gets dissolved and make up to 100ml with above solution.  

5.2.2 Sample solution:

Weigh and powder 20 tablets. Weigh accurately the tablets powder  equivalent to about 20mg of Montelukast sodium into 100ml of volumetric flask, add 50ml of double distilled water, shake well until dissolve the substance or Sonicate for 3 minutes, make up to volume with double distilled water. 

Filter the sample Solution with whatman filter paper and  reject first few ml of the filtrate. 

Measure the absorbance at about 260nm using double distilled water as blank

5.2.3 Calculate the content by comparison.

Sample absorbance    x  Standard weight  x Assay x Average weight of the tablet = 

Standard absorbance  x  Sample Weight   x   100     

= ____________x100

         LC 

LC: Label Claim

6.0 ANNEXURES

Nil