Estimation of Piroxicam (20mg) in tablet formulation

1.0 OBJECTIVE                    

To provide the procedure for the determination of Piroxicam (20mg)

2.0 SCOPE

This procedure is Applicable to the determination of Piroxicam (20mg)

3.0 RESPONSIBILITY 

3.1 QC-Chemist 

4.0 ACCOUNTABILITY         

4.1 Executive – Quality control

4.2 Head – Quality control

5.0 PROCEDURE         

 

 5.1 Label Claim: 

Each dispersible uncoated tablet contains:

Piroxicam  IP 20mg 

5.2 Assay Method: 

5.21 Preparation of standard solution:

Dissolve 100mg of the Piroxicam in 50ml of methanol and further diluted to 100ml with methanol.

Further dilute 10ml of the above solution into 100ml with methanol.

5.2.2 Preparation of Sample solution:

Weight powder twenty tablets and take the powder equivalent to100mg Piroxicam  was accurately weighed, dissolved in 100 ml of methanol, filtered through Whatmann filter paper No: 41. 

Further dilute 10ml of the above solution into 100ml with methanol.

5.2.3 Measure the absorbance at about 260nm

5.2.4 Calculate the content by comparison.

Sample absorbance    x  Standard weight  x Assay x Average weight of the tablet = 

Standard absorbance  x  Sample Weight   x   100     

= ____________x100

         LC 

LC: Label Claim

6.0 ANNEXURES

Nil